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| Hazard characterisation
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 ENFIRO performs a health hazard characterisation of the selected FRs with the focus on a molecular and cellular level. The emphasis is on human/mammalian geno-, endocrine- and neurotoxicity (sensitive targets for metals, nanoclays, PFRs and BFRs) in vitro studies, including biotransformation, and a limited number of ex vivo validation studies. |
The ecotoxicological hazard characterization studies investigate the acute toxicity using water and sediment toxicity tests (Daphnia, Chironomus riparius, algae PAM), and the chronic toxicity with the Daphnia, Lumbriculus variegates tests. Bioavailability is taken into account, and structure-activity relationships for toxicity is derived.
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